Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health. SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and supports neurotransmitter receptor affinity. SAM-e supports healthy joints both by helping increase the number of articular chondrocytes and by stimulating the synthesis of sulfated proteoglycans therein.
SAM-e also protects synovial cells and helps block enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions. SAM-e Plus tablets are enterically-coated, essential for preventing demethylation in the stomach.

Dietary considerations

Gluten free

Dairy free

Soy free

Salt free

Wheat free

Corn free

Yeast free

Sugar free

Preservative free

Artificial Color / Colour Free

Artificial Flavor / Flavour Free

Suggested use

Two to four capsules daily, or as directed by your health care practitioner.

Serving Size: 2 Capsules

Servings per container: 30

Amount Per Serving

B3 ... 30mg

(niacinamide)

B6 ... 2mg

(pyridoxine HCl)

Folic Acid ... 400mcg

B12 ... 20mcg

(cyanocobalamin)

SAM-e ... 400mg

(tosylate disulfate)

Choline ... 50mg

(bitartrate)

Other Ingredients

Vegetarian capsule (hypromellose and water), silica, magnesium stearate.