SAM-E

11 products

  • SAM-e 200 mg 60 tabs SAM-e 200 mg 60 tabs

    Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. Contains More of the Active S,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available. SAMe has been clinically shown to have the following benefits: Joint Strength SAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate. Brain Metabolism SAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin). Liver SAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body’s endogenous antioxidant network and important for liver function, including phase II detoxification. Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken. Full Potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate. For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.   Dietary Considerations Wheat Free Dairy/ Milk Free Gluten Free Vegetarian Soy Free Vegan Egg Free Shellfish Free Fish Free Tree Nut Free Peanut Free   Serving Size: 1 Tablet   Servings Per Container: 60   Amount Per Serving S-Adenosyl Methionine (from 400 mg of SAM-e tosylate disulfate) 200 mg   Other Ingredients: Cellulose, mannitol, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, sodium starch glycolate, enteric coating modified cellulose, magnesium silicate, triethyl citrate, riboflavin   Suggested Use Take 1 tablet 1 or 2 times per day on an empty stomach or as directed by your qualified healthcare professional. Suitable for vegetarians/vegans. No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.   WARNING Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended dose. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use. Jarrow Formulas SAM-e 200 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken. Contains More of the Active S,S Form Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.

    Out of stock

    $46.49$45.12

    Out of stock

  • Pure Encapsulations SAMe - S-Adenosylmethionine 60 caps Pure Encapsulations SAMe - S-Adenosylmethionine 60 caps

    Enhanced stability SAMe to support methylation, positive mood, glutathione production and joint comfortSAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids and proteins. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. SAMe also functions as a precursor molecule for glutathione and promotes polyamine synthesis to promote healthy cellular function.Clinical trials indicate that SAMe administration enhances glutathione production in hepatic tissue and red blood cells. SAMe also targets cognitive function and positive mood, as indicated in over 40 clinical studies. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood believed to be due to its support for neurotransmitter monoamine synthesis and function, including dopamine and serotonin.It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity. Studies suggest it may enhance joint comfort and flexibility as well. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. It is believed to enhance joint comfort and function by supporting proteoglycan synthesis, as well as helping to stabilize and protect the proteoglycans.• Supports cognitive and liver function• Helps maintain joint comfort• Made with hypoallergenic, vegan ingredientsDietary ConsiderationsGluten FreeNon-GMOServing Size: 1 CapsuleServings Per Container: 60Amount Per ServingSAMe (S-adenosylmethionine) (from S-adenosyl-L-methionine disulphate tosylate) 200 mgOther Ingredients:vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose), calcium oxide, Ascorbyl palmitate, Calcium chlorideAs a dietary supplement, take 1 capsule, 1–2 times daily, between meals, or as directed by a health professional.If you are pregnant or lactating, have any health condition or are taking any medication, particularly if you have bipolar disorder or are taking antidepressant medication, consult your health professional before use.Keep out of the reach of children.Use only if safety seal is intact. Store in a cool, dry place.

    $79.00

  • Karuna SAM-e Plus 60 tabs Karuna SAM-e Plus 60 tabs

    Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health. SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and supports neurotransmitter receptor affinity. SAM-e supports healthy joints both by helping increase the number of articular chondrocytes and by stimulating the synthesis of sulfated proteoglycans therein.* SAM-e also protects synovial cells and helps block enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions.* SAM-e Plus tablets are enterically-coated, essential for preventing demethylation in the stomach.   Dietary Considerations Wheat Free Dairy/ Milk Free Gluten Free Soy Free Yeast Free Sugar Free Preservative Free Salt Free Corn Free Free of Artificial Colors/Flavors   Serving Size:2 Tablet   Servings Per Container:30    Amount Per Serving B3 (niacinamide) 30 mg   B6 (pyridoxine HCI) 2 mg   Folic Acid 400 mcg   B12 (cyanocobalamin) 20 mcg   SAM-e (tosylate disulfate) 400 mg   Choline (bitartrate) 50 mg     Other ingredients: calcium sulfate, vegetable stearine, silica, vegetable coating       Suggested use for adults: Two to four tablets daily, preferably morning and evening, or as directed by your health care practitioner. *Enterically coated tablets  This product container no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring. This product is intended for professional use and is manufactured under strict quality control to ensue the optimum in purity, potency and reliability.  Keep in a cool, dry place, tightly capped.    

    $78.00

  • Progressive Labs SAMe Forte 200 mg 30 tabs Progressive Labs SAMe Forte 200 mg 30 tabs

    "Progressive Labs SAMe-200 is an enteric coated tablet containing 200 mg of S-adenosyl-methionine. S-adenosyl-l-methionine (SAMe) is an important biological agent in the human body, participating in over 40 essential biochemical reactions. SAMe is normally produced in the liver from the amino acid methionine which is abundant in most diets. Low blood or central nervous system levels of SAMe have been detected in people with cirrhosis of the liver, coronary heart disease, Alzheimer’s disease, and depression.SAMe functions as a methyl group donor in reaction catalyzed by methyltransferase enzymes. SAMe also serves as a precursor molecule for glutathione synthesis.‡SAMe-200 is in an enteric coated tablet to allow for disintegration and optimal absorption in the intestinal tract.   Suggested UseOne enteric coated tablet daily, on an empty stomach, or as directed by a health care professional.   Serving Size: 1 Tablet   Servings Per Container: 30   Amount Per Serving B-6 (pyridoxine HCl) 20 mg Folic Acid 200 mcg B-12 (cyanocobalamin) 14 mcg SAM-e (from S-Adenosyl-Methionine Disulfate Tosylate) 200 mg   Other Ingredients dicalcium phosphate, powdered cellulose, croscarmellose sodium, stearic acid, silicon dioxide, magnesium stearate, vanilla flavoring   Warnings Sold only for dispensing by a licensed health care professional. TAMPER EVIDENT BAND AROUND CAP AND SEAL ON BOTTLEDO NOT USE IF EITHER SEAL IS BROKEN OR MISSINGKEEP OUT OF REACH OF CHILDREN Individuals being treated for neurological conditions should consult their health care practitioners before using this product. Individuals with bipolar (manic) depression should take SAMe only under professional medical supervision. Seal tightly after each use. KEEP REFRIGERATED. Heat Sensitive: Overnight shipping is recommended. Not recommended for international shipping.

    Out of stock

    $40.00

    Out of stock

  • Bioclinic Naturals SAMe 30 tabs Bioclinic Naturals SAMe 30 tabs

    Supports joint health and emotional well-being. Contains 200 mg of the highest quality Italian Isoactive SAMe available on the market. Isoactive uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations. Enteric coated to ensure a biologically active product. Contains no artificial preservatives or sweeteners; no dairy, gluten, soy, wheat or yeast. Bioclinic Naturals products are guaranteed to meet or exceed Good Manufacturing Practices (GMP) of the Canadian Government and the Therapeutic Goods Administration (TGA) regulations of Australia— among the world’s highest standards for natural products.   Serving Size 1 Tablet   Amount Per Serving SAMe S-Adenosyl-L-Methionine 200 mg (from 400 mg SAMe Tosylate Disulfate)   Other ingredients Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides (coconut), yellow iron oxide), glyceryl behenate, magnesium stearate (vegetable grade), silica, sodium starch glycolate.   Suggested Use Take on an empty stomach For mood balance: 1–4 tablets 2 times per day or as directed by a health care professional. For joint support: 1–3 tablets 2 times per day or as directed by a health care professional. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.   Warning If you are taking anti-depressant medications, consult a health care professional prior to taking SAMe in place of or in addition to those medications. Not recommended for use in children. Do not use if you are pregnant or breastfeeding. Do not take at night as SAMe may cause anxiety, restlessness, insomnia. People with bipolar disorder or (manic-depressive illness) should not use SAMe unless under medical supervision. Possible side effects are: mild gastrointestinal upsets (such as stomach pain, nausea, diarrhea, flatulence), anxiety, hyperactive muscle movement, insomnia and hypomania. When these side effects occur, they often diminish with time or resolve with lower doses or cessation of use. There are no documented cases of allergies to SAMe. Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

    $30.99$30.28

  • Source Naturals SAMe 400mg 30 tabs Source Naturals SAMe 400mg 30 tabs

    Source Naturals SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage. The studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe also plays a role in transmethylation. Transmethylation reactions affect the synthesis, activation, and metabolism of various biological molecules. Some compounds that SAMe methylates are phospholipids. This is a fundamental step in the mediation of cell to cell communication. SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. However, levels of SAMe tend to decline with age.* Suitable for vegetarians.* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    $47.50$45.58

  • Metabolic Maintenance SAMe 200 mg 60 caps Metabolic Maintenance SAMe 200 mg 60 caps

    Naturally occurring in our bodies, SAMe is one versatile molecule. It is used as a critical methyl donor throughout the body aiding in cellular protection. SAMe crosses the blood-brain barrier and contributes to the formation of dopamine, serotonin and norepinephrine, supporting balanced mood. It has also been shown to promote healthy joint function and liver health. Though versatile and effective, the molecule can be unstable. Metabolic Maintenance's form combines SAMe with calcium making it less sensitive to humidity and temperature. This means you can get the benefits of SAMe without ingesting the chemicals involved in a coated tablet or hassling with refrigeration. To promote maximum efficacy, Metabolic Maintenance provides their clean version of SAMe in acid resistant capsules for release in the intestine.• Promotes positive mood• Improves brain function• Supports healthy joints• Stable, acid-resistant formulation   Dietary Considerations Dairy/ Milk Free Gluten Free Egg Free Tree Nut Free Peanut Free   Suggested Use One to two (1-2) capsules daily, between meals, or as directed by a healthcare professional.   Serving Size: 1 Capsule   Servings Per Container: 60   Amount Per Serving % Daily Value Calcium (as Calcium Citrate) 20 mg 2% Magnesium (as Magnesium Citrate) 20 mg 5% SAMe (from 444 mg S-Adenosyl-L-methionine disulfate p-toluensulfonate, calcium chloride, calcium oxide) 200 mg   Other Ingredients: L-leucine, Vegetarian cellulose, gellan gum capsule   Warnings Pregnant or lactating women, consult your healthcare professional before taking this product. If you suffer from bipolar (manic) depression, do not use this product.Keep tightly closed, dry place out of the reach of children.

    $66.80

  • Source Naturals SAMe 200mg 60 tabs Source Naturals SAMe 200mg 60 tabs

    Source Naturals® SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients.Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.The studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe also plays a role in transmethylation. Transmethylation reactions affect the synthesis, activation, and metabolism of various biological molecules.Some compounds that SAMe methylates are phospholipids. This is a fundamental step in the mediation of cell to cell communication. SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. However, levels of SAMe tend to decline with age.** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    $58.98$56.14

  • Jarrow Formulas SAM-e 400 mg 30 tabs Jarrow Formulas SAM-e 400 mg 30 tabs

    Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.Contains More of the Active S,S FormFound in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.SAMe has been clinically shown to have the following benefits:Joint StrengthSAMe supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate.Brain MetabolismSAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).LiverSAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body's endogenous antioxidant network and important for liver function, including phase II detoxification. Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken. Full Potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate. For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon   Dietary Considerations Wheat FreeDairy/ Milk FreeGluten FreeVegetarianSoy FreeVeganEgg FreeShellfish FreeFish FreeTree Nut FreePeanut Free   Serving Size: 1 Tablet   Servings Per Container: 30   Amount Per ServingS-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate)400 mg   Other Ingredients:Cellulose, glyceryl behenate, magnesium stearate (vegetable source), silicon dioxide, mannitol, sodium starch glycolate, an enteric coating (modified cellulose, magnesium silicate, triethyl citrate and riboflavin).   Suggested Use Take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.   Warning No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts. Suitable for vegetarians/vegans.Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinsons disease, bi-polar disorder or manic depression should not use SAM-e. Do not use if pregnant or nursing. Do not exceed recommended intake. May cause gastrointestinal upset in some persons. If you experience discomfort, discontinue use.Store in a cool, dry place. Keep out of reach of children. Jarrow Formulas SAM-e 400 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.

    $48.99$47.44

  • Protocol for Life Balance SAMe 200 mg 60 tabs Protocol for Life Balance SAMe 200 mg 60 tabs

    SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to alleviate transient normal aches and pains resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in the maintenance of a positive mood.• Supports Nervous System and Joint Health• Stabilized SAMe, Capsule Form• No Enteric Coating NeededDietary ConsiderationsWheat FreeDairy/ Milk FreeGluten FreeVegetarianSoy FreeVeganEgg FreeShellfish FreeFish FreeTree Nut FreeServing Size: 1 Vegetable CapsuleServings Per Container: 60Amount Per ServingSAMe (S-Adenosyl-L-Methionine) (from S-Adenosyl-L-Methionine Disulfate Tosylate) 200 mgOther Ingredients:Hypromellose (cellulose capsule), Microcrystalline Cellulose, Silicon Dioxide, Stearic Acid (vegetable source)Take 1 capsule 2 to 4 times daily, or as directed by your healthcare practitioner.Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.Natural color variation may occur in this product.Cautions/Interactions: Theoretically, SAMe could increase the effects and adverse effects of products that increase serotonin levels, including 5-hydroxytryptophan (5-HTP), Hawaiian baby woodrose, L-tryptophan, and St. John's wort. In addition, SAMe may interact with MAO inhibitors, L-Dopa, antidepressants and other serotonergic drugs. Consult healthcare practitioner if pregnant/nursing, taking medication, or have a medical condition, especially bipolar or anxiety disorders.

    $40.99

  • Metabolic Maintenance SAMe + CoFactors 200 mg 60 caps Metabolic Maintenance SAMe + CoFactors 200 mg 60 caps

    SAMe is a critical methyl donor for several important reactions in the body including the formation of healthy levels of neurotransmitters. Other nutrients contribute to the cycle of methylation reactions as well. Metabolic Maintenance offers SAMe with its nutrient cofactors to provide an easy-to-take product to support methylation processes in the body.• Promotes the conversion of homocysteine back to SAMe• Nourishes healthy neurotransmitter formation• Supports balanced mood   Dietary Considerations Dairy/ Milk Free Gluten Free Egg Free Tree Nut Free Peanut Free   Suggested Use One to two (1-2) capsules daily, between meals, or as directed by a healthcare professional.   Serving Size: 1 Capsule   Servings Per Container: 60   Amount Per Serving % Daily Value Vitamin B-6 (as Pyridoxal 5’ Phosphate) 2 mg 118% Folate (200 mcg from L-5-Methylfolate, glucosamine salt) DFE 333 mcg 83% Vitamin B-12 (as Methylcobalamin) 500 mcg 20833% Calcium (as Calcium Citrate) 20 mg 2% Magnesium (as Magnesium Citrate) 20 mg 5% SAMe (from 444 mg S-Adenosyl-L-methionine disulfate p-toluensulfonate, calcium chloride, calcium oxide) 200 mg   Other Ingredients: L-leucine, vegetarian cellulose and gellan gum capsule   Warnings Pregnant or lactating women, consult your healthcare professional before taking this product. If you suffer from bipolar (manic) depression, do not use this product. Keep tightly closed, dry place out of the reach of children.

    $73.00

SAM-E Products

SAM-E refers to S-adenosy-L-methionine and it comprises of ATP and amino acid methionine. Technically, SAM-E is involved in the manufacturing of various important compounds in the body. It is found in every cell of the body and naturally, its levels fall with ageing. It is a natural anti-depressant and promotes normal brain cell functions.

Being involved in numerous bodily chemical reactions, SAM-E is essential for healthy nerve functions and cell maintenance. Natural SAM-E supplements are known to affect a number of conditions including Fybromyalgia, depression, liver diseases and osteoarthritis. Some holistic experts believe it offers pain relief without the usual side-effects of aspirin. SAM-E is also known to help in fight against cholestasis, migraines and Gilbert's syndrome.

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