5-MTHF ES provides 17,000 mcg of 5-MTHF (5-methyltetrahydrofolate) per serving. 5-MTHF is the most biologically active form of the water-soluble B vitamin, folate;  and it may be the preferred form for those with variations in digestion, absorption, or folate metabolism. Data suggest that in comparison to synthetic folic acid, 5-MTHF increases plasma folate more effectively. In this formula, 5-MTHF is provided as Quatrefolic—the glucosamine salt of 5-MTHF. Quatrefolic has demonstrated greater stability, solubility, and bioavailability when compared to calcium salt forms of 5-MTHF.

Dietary considerations

Gluten free

Dairy free

Soy free

Egg free

Tree nut free

Fish free

Peanut free

Shellfish free

Wheat free

Animal product free

Corn free

Yeast free

Suggested use

Take one to two capsules daily, or as directed by your healthcare professional.

Serving Size: 2 Capsules

Servings per container: 30

Amount Per Serving

Folate … 17,000 mcg DFE (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt)

Other Ingredients

Microcrystalline cellulose, capsule (hypromellose and water), stearic acid, magnesium stearate, and silica.

Formulated to Exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.