Melatonin is a hormone (NÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬ÃƒÂ¢Ã¢â€šÂ¬Ã‹Å“acetyl-5ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬ÃƒÂ¢Ã¢â€šÂ¬Ã‹Å“methoxytryptamine) produced especially at night in the pineal gland. Its secretion is stimulated by darkness and inhibited by light. Melatonin, an indole, is synthesized from tryptophan via serotonin. The suprachiasmatic nuclei (SCN) of the hypothalamus have melatonin receptors and melatonin may have a direct action on SCN to help influence circadian (sleep) rhythms.* ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â Dietary Considerations Wheat Free Dairy/ Milk Free Gluten Free Soy Free Yeast Free Sugar Free Starch Free Preservative Free Corn Free Free of Artificial Colors/Flavors Egg Free ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â Serving Size:4 Spray ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â Servings Per Container:100 ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â Amount Per Serving Melatonin (N-acetyl-5-methoxytryptamine)1760 mcg ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â Other Ingredients: Natural peppermint extract, ethanol, glycerin, purified water ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â Directions of use: Adults: Spray 4ÃƒÆ’Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬ÃƒÂ¢Ã¢â€šÂ¬Ã…â€œ22 times daily under the tongue (4, 11, and 22 sprays provide approximately 1.5, 5, and 10 mg of melatonin, respectively) or as directed by your health-care practitioner. Sensitivity to melatonin is different from person to person. Take once a day, at or before bedtime. For jet lag: Take once a day at bedtime after darkness has fallen, while travelling and at destination, until adaptation to the new daily pattern on occasional short-term use. For sleep restriction / altered sleep schedule, for delayed sleep phase disorder, and to restore sleep/wake cycle: Consult a health-care practitioner for use beyond 4 weeks or if symptoms persist for more than 4 weeks (chronic insomnia). ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar. ÃƒÆ’Ã¢â‚¬Å¡Ãƒâ€šÃ‚Â Cautions and warnings: Consumption with alcohol, other medications, or natural health products with sedative properties is not recommended. Consult a health-care practitioner prior to use if you are taking anticoagulants, anticonvulsants, blood-pressure medications, immunosuppressive medications, sedatives, hypnotic or psychotropic medications, or steroids. Consult a health-care practitioner prior to use if you have asthma, cardiovascular disease, chronic kidney disease, depression, diabetes or hypoglycaemia, hormonal disorder, immune system disease, liver disease, migraine, or seizure disorder. Contraindications: Do not use if you are pregnant or breast-feeding. Do not drive or use machinery for 5 hours after taking melatonin. Known adverse reactions: Mild gastrointestinal symptoms (nausea, vomiting, or cramping) have been known to occur; in which case, discontinue use. Rare allergic reactions have been known to occur; in which case, discontinue use. Do not use if seal is broken. Keep out of reach of children.