Professional Formulas
Professional Formulas

Professional Formulas

968 products

  • Professional Formulas Pure Liver - 90 Capsules Professional Formulas Pure Liver - 90 Capsules

    Serving Size: 3 CapsulesActive Ingredients:Liver tissue (bovine) 1500mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, and vegetable medium chain triglycerides.Gluten FreeGlandularHypoallergenicIndications:Lyophilized liver glandular.Recommended Dosage: As a nutritional supplement, take 1-3 capsules every four hours, not to exceed 12 capsules daily, or as directed by your healthcare professional. Intended for temporary use.

    $22.00

  • Professional Formulas St. Mary's Thistle (Silybum marianum) - 8.4 FL. OZ. (250 mL) Professional Formulas St. Mary's Thistle (Silybum marianum) - 8.4 FL. OZ. (250 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:Milk Thistle (Silybum marianum) Seed Extract (1:1) 4.9mLOther Ingredients: Grain alcohol (45%) and purified water.Botanical Name: Silybum marianumSeed1:1Vegetarian FormulaGluten FreeHypoallergenicRecommended Dosage: Not intended for use during pregnancy.

    $55.20

  • Professional Formulas Reishi (Ganoderma lucidum) - 8.4 FL. OZ. (250 mL) Professional Formulas Reishi (Ganoderma lucidum) - 8.4 FL. OZ. (250 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:Reishi (Ganoderma lucidum) Mushroom Extract (1:1) 4.9mLOther Ingredients: Grain alcohol (43%) and purified water.Botanical Name: Ganoderma lucidumMushroom1:1Vegetarian FormulaGluten FreeHypoallergenicRecommended Dosage: May increase the risk of bleeding in some people. Not intended for use while pregnant or breastfeeding.

    $55.20

  • Professional Formulas Jamaican Dogwood (Piscidia piscipula) - 8.4 FL. OZ. (250 mL) Professional Formulas Jamaican Dogwood (Piscidia piscipula) - 8.4 FL. OZ. (250 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:Jamaican Dogwood (Piscidia piscipula) Bark Extract (1:1) 4.9mLOther Ingredients: Grain alcohol (30%) and purified water.Botanical Name: Piscidia piscipulaBark1:1Vegetarian FormulaGluten FreeHypoallergenic

    $58.00

  • Professional Formulas PhytoMetabolize - 120 Capsules Professional Formulas PhytoMetabolize - 120 Capsules

    Serving Size: 4 CapsulesActive Ingredients:Garcinia (Garcinia cambogia) Fruit Rind Extract (65% Ca-HCA) 1280mgDark Cocoa (Theobroma cacao) Fruit Extract 200mgGreen Tea (Camellia sinensis) Leaves Extract (80% polyphenols/30% EGCG) 200mgDandelion (Taraxacum officinale) Root 160mgPrickly Pear Cactus (Opuntia ficus-indica) Aerial Parts 20:1 Extract 160mgGinger (Zingiber officinale) Root Extract 120mgTriphala (Terminalia chebula/Emblica officinalis/Terminalia belerica) Fruit Extract (40% tannins) 120mgHoodia (Hoodia gordonii) Stem 80mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, and vegetable medium chain triglycerides.Vegetarian FormulaGluten FreeHypoallergenicIndications:Support for healthy eating habits, digestion and blood sugar metabolism.Recommended Dosage: As a nutritional supplement, take 4 capsules daily, or as directed by your healthcare professional.

    Out of stock

    $34.00

    Out of stock

  • Professional Formulas Cardio Clear - 180 Capsules Professional Formulas Cardio Clear - 180 Capsules

    Serving Size: 3 CapsulesActive Ingredients:Vitamin A (as retinyl palmitate) 1800mcg RAE (6000IU)Vitamin C (as L-ascorbic acid/sodium ascorbate/zinc ascorbate) 334mgMagnesium (as oxide) 165mgZinc (as ascorbate) 12mgSelenium (as aspartate) 36mcgSodium (as ascorbate) 15mgPotassium (50% aspartate/50% citrate) 105mgDisodium EDTA 510mgCilantro (Coriandrum sativum) Leaves 255mgBromelain (2,400 GDU/g) 206mgEnglish Hawthorn (Crataegus laevigata) Fruit 75mgArjun (Terminalia arjuna) Bark 15:1 Extract 45mgBoswellia (Boswellia serrata) Gum Resin Extract (65% boswellic acid) 45mgBrahmi (Bacopa monnieri) Aerial Parts Extract (50% bacosaponins) 45mgChinese Hibiscus (Hibiscus rosa-sinensis) Flower 20:1 Extract 45mgGarlic (Allium sativum) Bulb 45mgGinger (Zingiber officinale) Root Extract (5% gingerol) 45mgTurmeric (Curcuma longa) Root 45mgL-Glutathione 15mgPapain (2000 USP/mg) 3mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, vegetable medium chain triglycerides, and vegetable stearate.Vegetarian FormulaGluten FreeHypoallergenicNot intended for children.Indications:Assists the body in maintaining a healthy circulatory system.Recommended Dosage: As a nutritional supplement, take 1-3 capsules three times daily, or as directed by your healthcare professional.

    Out of stock

    $46.00

    Out of stock

  • Professional Formulas Borage Seed Oil - 90 Perles Professional Formulas Borage Seed Oil - 90 Perles

    Serving Size: 1 PerleActive Ingredients:Borage (Borago officinalis L.) Oil 1000mgLinoleic acid 280mgGamma-linoleic acid (GLA) 160mgOleic acid 90mgOther Ingredients: Gelatin, glycerin, purified water, and mixed tocopherols.Gluten FreeHypoallergenicIndications:Borage seed oil is rich in omega-6 essential fatty acids, which may be used to reduce the symptoms of inflammatory conditions such as rheumatoid arthritis and female conditions, including PMS.Recommended Dosage: As a nutritional supplement, take one perle 3 times daily, or as directed by your healthcare professional.

    $32.00

  • Professional Formulas Trace Mineral Complex - 4 FL. OZ. (118 mL) Professional Formulas Trace Mineral Complex - 4 FL. OZ. (118 mL)

    Serving Size: 1 Teaspoon (4.9 mL)Active Ingredients:Calcium (as calcium lactate) 0.34mgMagnesium (as magnesium gluconate) 0.63mgZinc (as zinc gluconate) 0.16mgCopper (as copper gluconate) 1.84mgManganese (as manganese gluconate) 0.2mgChromium (as chromium chloride) 14.29mcgMolybdenum (as ammonium molybdenum) 14.29mcgSodium (as sodium phosphate) 0.49mgSodium (as sodium selenite) 0.01mgPotassium (as potassium gluconate) 0.08mgPotassium (as potassium iodine) 0.01mgSilicon (as silicon lactate) 14.29mcgVanadium (as vanadium sulfate) 14.29mcgOther Ingredients: Purified water, ethanol (10%), and vegetable glycerin (from soy) (8%).Vegetarian FormulaGluten FreeIndications:Ionized microminerals.Recommended Dosage: As a nutritional supplement, take one teaspoon daily, or as directed by your healthcare professional.

    Out of stock

    $22.50

    Out of stock

  • Professional Formulas Liquid DHEA - 2 FL. OZ. (59 mL) Professional Formulas Liquid DHEA - 2 FL. OZ. (59 mL)

    Serving Size: 1 Drop (0.03 mL)Active Ingredients:Dehydroepiandrosterone (DHEA) 1.5mgOther Ingredients: Ethanol (53%), vegetable glycerin (from soy) (45%), and herbal flavoring mixture containing extracts of licorice and anise (2%).Vegetarian FormulaNot intended for children under 12 years of age.Indications:Nutritional supporting for maintaining healthy DHEA regulation.Recommended Dosage: As a nutritional supplement, take one drop up to 3 times daily, or as directed by your healthcare professional.

    $42.00

  • Professional Formulas Forest Immunity - 90 Capsules Professional Formulas Forest Immunity - 90 Capsules

    Serving Size: 2 CapsulesActive Ingredients:Cordyceps (Cordyceps militaris & Cordyceps sinensis) Mushroom 600mgShiitake (Lentinula edodes) Mushroom Mycelia 400mgMaitake (Grifola frondosa) Mushroom Fruiting Bodies & Mycelia 200mgReishi (Ganoderma lucidum) Mushroom Mycelia 200mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, and vegetable medium chain triglycerides.Vegetarian FormulaGluten FreeHypoallergenicIndications: A synergistic blend of mushrooms to assist in healthy immune function. May also promote healthy cardiovascular, metabolic, liver, kidney, and lung function.Recommended Dosage: As a nutritional supplement, take two capsules up to 3 times daily with plenty of water, or as directed by your healthcare professional.

    $32.00

  • Professional Formulas Chastetree (Vitex agnus-castus) - 8.4 FL. OZ. (250 mL) Professional Formulas Chastetree (Vitex agnus-castus) - 8.4 FL. OZ. (250 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:Chastetree (Vitex agnus-castus) Berry Extract (1:1) 4.9mLOther Ingredients: Grain alcohol (44%) and purified water.Botanical Name: Vitex agnus-castusBerry1:1Vegetarian FormulaGluten FreeHypoallergenicRecommended Dosage: Not intended for use during pregnancy.

    $47.50

  • Professional Formulas Vitamin C 1000 Plus 180t Professional Formulas Vitamin C 1000 Plus 180t

    Sustained release.Vitamin C (L-ascorbic acid) 1000 mg Lemon bioflavonoids 500 mg Rose hips (Rosa canina) 50 mg Hesperidin complex 50 mg Rutin 50 mg

    $44.00

  • Professional Formulas Turmeric - 90 Capsules Professional Formulas Turmeric - 90 Capsules

    Serving Size: 1 CapsuleActive Ingredients:Turmeric (Curcuma longa) Root Extract (95% curcuminoids) 250mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, and vegetable medium chain triglycerides.Vegetarian FormulaGluten FreeHypoallergenicIndications:Supports joint, tissue, liver, colon and cellular health.Recommended Dosage: As a nutritional supplement, take one capsule 2 times daily, or as directed by your healthcare professional.

    Out of stock

    $32.00

    Out of stock

  • Professional Formulas Pancreatin 8X Plus - 60 Capsules Professional Formulas Pancreatin 8X Plus - 60 Capsules

    High potency pure pancreatic enzymes.Pancreatin (8X) 725 mg Trypsin 21 mg Chymotrypsin 2 mg Enzyme activity per capsule: Amylase 200, 000 USP Protease 145, 000 USP Lipase 31, 000 USP Trypsin 5, 100 USP Chymotrypsin 2, 000 USP

    $32.00

  • Professional Formulas Oats (Avena sativa) - 8.4 FL. OZ. (250 mL) Professional Formulas Oats (Avena sativa) - 8.4 FL. OZ. (250 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:Oats (Avena sativa) Aerial Parts Extract (1:1) 4.9mLOther Ingredients: Grain alcohol (45%) and purified water.Botanical Name: Avena sativaAerial Parts1:1Vegetarian FormulaGluten FreeHypoallergenic

    $42.00

  • Professional Formulas Crataeva nurvala - 16 FL. OZ. (473 mL) Professional Formulas Crataeva nurvala - 16 FL. OZ. (473 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:Varuna (Crataeva nurvala) Bark Extract (1:1) 4.9mLOther Ingredients: Grain alcohol (45%) and purified water. Botanical Name: Crataeva nurvala Bark 1:1 Vegetarian Formula Gluten Free Hypoallergenic

    $91.00

  • Professional Formulas Collagen Complex - 180 Capsules Professional Formulas Collagen Complex - 180 Capsules

    Serving Size: 1 CapsuleActive Ingredients:Vitamin A (as beta-carotene) 600mcg RAE (2000IU)Vitamin C (as L-ascorbic acid) 100mgVitamin E (as succinate) (from soy) 20mg alpha-tocopherol (30IU)Calcium (as aspartate) 30mgMagnesium (as aspartate) 30mgZinc (as aspartate) 10mgManganese (as aspartate) 50mgCollagen (as bovine cartilage tissue) 200mgMicrocrystalline hydroxyapatite (bovine) 50mgChondroitin sulfate (bovine) 40mgCitrus bioflavonoid complex 19mgHesperidin 19mgRutin 10mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, and vegetable medium chain triglycerides. CONTAINS: Soy.Gluten FreeGlandularIndications:Nutritional support for healthy tendons, ligaments and cartilage.Recommended Dosage: As a nutritional supplement, take one capsule up to 4 times daily following meals, or as directed by your healthcare professional.

    Out of stock

    $56.00

    Out of stock

  • Professional Formulas CerebroTone - 180 Capsules Professional Formulas CerebroTone - 180 Capsules

    Serving Size: 4 CapsulesActive Ingredients:Ginkgo (Ginkgo biloba) Leaves Extract (24% flavone glycosides/6% terpene lactones) 500mgGotu Kola (Centella asiatica) Aerial Parts 4:1 Extract 350mgDamiana (Turnera diffusa) Leaves 4:1 Extract 300mgSkullcap (Scutellaria lateriflora) Aerial Parts 4:1 Extract 300mgSt. John’s Wort (Hypericum perforatum) Aerial Parts Extract (0.3% hypericin) 150mgEleuthero (Eleutherococcus senticosus) Root 4:1 Extract 100mgVinpocetine (from Voacanga africana Seed) 10mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, and vegetable medium chain triglycerides.Vegetarian FormulaGluten FreeHypoallergenicIndications:Herbs that support brain and nervous system health.Recommended Dosage: As a nutritional supplement, take 2-4 capsules three times daily, or as directed by your healthcare professional.

    $32.00

  • Professional Formulas Lymph Stim Liquescence - 4 FL. OZ. (118 mL) Professional Formulas Lymph Stim Liquescence - 4 FL. OZ. (118 mL)

    Serving Size: 1 Teaspoon (4.9 mL)Active Ingredients:Scrophularia nodosa 1XEchinacea angustifolia 2XEchinacea purpurea 2XCitrus limonum 3XSilicea 3XSilicea 6XSilicea 12XPhytolacca decandra 4XThuja occidentalis 4XCapsicum annuum 6XHydrastis canadensis 6XLymph 6XMammary 6XSpleen 6XThymus 6XArsenicum iodatum 12XLachesis mutus 12XBase Ingredients: 20% ethanol, purified water.Gluten FreeGlandularHypoallergenicIndications:For the temporary relief of swelling of extremities, minor joint aches or discomfort, decreased flexibility, fatigue, or dry, itchy skin.Recommended Dosage: Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take one full dropper up to 2 times per day. Consult a physician for use in children under 12 years of age.

    $22.50

  • Professional Formulas Red Alaskan Sea Dulse Spray - 1 FL. OZ. (29.5 mL) Professional Formulas Red Alaskan Sea Dulse Spray - 1 FL. OZ. (29.5 mL)

    Serving Size: 2 Sprays (0.33 mL)Active Ingredients:Zinc (as gluconate) 4.4mgDesert Parsley (Lomatium dissectum) Root 1:2 Extract 16.5Mullein (Verbascum thapsus) Leaves 1:2 Extract 16.5Echinacea purpurea Root 1:1 Extract 9.9Licorice (Glycyrrhiza glabra) Root 1:1 Extract 8.8Echinacea angustifolia Aerial Parts 1:1 Extract 6.6Goldenseal (Hydrastis canadensis) Root 1:2 Extract 4.4Red Dulse 1:100 Extract 3.3Anise (Pimpinella anisum) Seed 1:1 Extract 2.2Other Ingredients: Vegetable glycerin (from soy) (20%), grain alcohol (7%), cane alcohol (3%), and purified water. CONTAINS: SoyVEGETARIAN FORMULAGLUTEN FREEBotanical throat spray.Recommended Dosage: As a nutritional supplement, take 1-2 sprays daily into the back of the throat, or as directed by your healthcare professional.

    $22.00

  • Professional Formulas Parathyroid Complex - 60 Capsules Professional Formulas Parathyroid Complex - 60 Capsules

    Serving Size: 1 CapsuleActive Ingredients:Vitamin D3 (as cholecalciferol) 10mcg (400IU)Calcium (as aspartate) 100mgMagnesium (as aspartate) 100mgSpleen tissue (bovine) 50mgParathyroid tissue (bovine) 5mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, and vegetable medium chain triglycerides.Gluten FreeGlandularHypoallergenicIndications:Parathyroid and spleen glandulars with synergistic ingredients.Recommended Dosage: As a nutritional supplement, take one capsule up to 4 times daily following meals, or as directed by your healthcare professional.

    $24.00

  • Professional Formulas Vitamin C 1000 Plus - 180 Capsules Professional Formulas Vitamin C 1000 Plus - 180 Capsules

    Serving Size: 2 CapsulesActive Ingredients:Vitamin C (as L-ascorbic acid) 1000mgLemon bioflavonoid complex 500mgHesperidin 50mgRosehips (Rosa canina) Fruit 50mgRutin 50mgOther Ingredients: Vegetarian capsule (hypromellose and water), vegetable medium chain triglycerides, and organic brown rice.Vegetarian FormulaGluten FreeHypoallergenicIndications:A high potency formula for supplementing vitamin C.Recommended Dosage: As a nutritional supplement, take two capsules up to 3 times daily, or as directed by your healthcare professional.

    $32.00

  • Professional Formulas Spilanthes Plus - 4 FL. OZ. (118 mL) Professional Formulas Spilanthes Plus - 4 FL. OZ. (118 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:Paracress (Spilanthes acmella) Flowering Tops Extract (1:10) 1.22mLJuniper (Juniperus communis) Berry Extract (1:2.5) 0.82mLOregon Grape (Mahonia aquifolium) Root Extract (1:2.5) 0.82mLPau D'Arco (Tabebuia avellanedae) Bark Extract (1:2.5) 0.82mLGum Myrrh (Commiphora molmol) Resin Extract (1:2) 0.61mLUsnea barbata Lichen Extract (1:2.5) 0.61mLOther Ingredients: Ethanol (49%) and purified water.Vegetarian FormulaGluten FreeHypoallergenicIndications:Supports healthy immune system function.Recommended Dosage: As a nutritional supplement, take one teaspoon 2 times daily, or as directed by your healthcare professional. Not intended for use during pregnancy.

    $30.00

  • Professional Formulas Licorice (Glycyrrhiza glabra) - 8.4 FL. OZ. (250 mL) Professional Formulas Licorice (Glycyrrhiza glabra) - 8.4 FL. OZ. (250 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:Licorice (Glycyrrhiza glabra) Root Extract (1:1) 4.9mLOther Ingredients:  Grain alcohol (42%) and purified water. Botanical Name: Glycyrrhiza glabra Root 1:1 Vegetarian Formula Gluten Free Hypoallergenic Recommended Dosage: May interfere with blood regulation and metabolism of other drugs. Not intended for use while pregnant or breastfeeding.

    $47.50

  • Professional Formulas Epstein Barr 500x 2oz Professional Formulas Epstein Barr 500x 2oz

    Serving Size: 10 DropsActive Ingredients:Epstein Barr Virus 500XBase Ingredients: 20% ethanol, purified water.Vegetarian FormulaGluten FreeHypoallergenicINDICATIONS: To be used according to standard homeopathic indications.Recommended Dosage: Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take 10 drops up to 3 times per day. Consult a physician for use in children under 12 years of age.

    $26.00

  • Professional Formulas California Poppy (Eschscholzia californica) - 8.4 FL. OZ. (250 mL) Professional Formulas California Poppy (Eschscholzia californica) - 8.4 FL. OZ. (250 mL)

    Serving Size: One Teaspoon (4.9 mL)Active Ingredients:California Poppy (Eschscholzia californica) Aerial Parts Extract (1:2) 4.9mLOther Ingredients: Grain alcohol (41%) and purified water.Botanical Name: Eschscholzia californicaAerial Parts1:2Vegetarian FormulaGluten FreeHypoallergenicRecommended Dosage: Not intended for use during pregnancy.

    $48.00

  • Professional Formulas Airborne Allersode - 2 FL. OZ. (59 mL) Professional Formulas Airborne Allersode - 2 FL. OZ. (59 mL)

    Serving Size: 10 DropsActive Ingredients:Adrenal 6XACTH 6XACTH 30XLiver 6XLiver 12XHistaminum hydrochloricum 12Xand all the following at 6X, 12X, 60X, 100X:Animal MixDust/Mold MixFlower MixGrass/Weed MixTree MixBase Ingredients: 20% ethanol, purified water.Gluten FreeGlandularIndications:For the temporary relief of runny nose, sneezing, itching of the nose or throat, and itchy, watery eyes due to sensitivity to inhalant/airborne allergens from trees, flowers, grass and weeds, dusts, molds, and animals.Homeopathic attenuations of the most common airborne allergens including trees, flowers, grass and weeds, dusts, molds, and animals.Recommended Dosage: Place drops under tongue 30 minutes before/after meals. Adults and children 12 years and over: Take 10 to 15 drops up to 3 times per day. For desensitization, begin with 1 to 5 drops daily, increasing to the standard dose gradually to avoid symptom expression; after 1 to 3 months at the standard dose, decrease gradually to a maintenance dose of 10 to 15 drops weekly. Consult a physician for use in children under 12 years of age.

    $23.50

  • Professional Formulas Ginkgo Biloba - 90 Capsules Professional Formulas Ginkgo Biloba - 90 Capsules

    Serving Size: 1 CapsuleActive Ingredients:Ginkgo (Ginkgo biloba) Leaves 550mgGinkgo (Ginkgo biloba) Leaves Extract (24% flavone glycosides/6% terpene lactones) 56mgOther Ingredients: Vegetarian capsule (hypromellose and water), organic brown rice, and vegetable medium chain triglycerides.Vegetarian FormulaGluten FreeHypoallergenicIndications: Ginkgo biloba is intended as a nutritional dietary aid to support memory, concentration, and other cognitive skills.Recommended Dosage: As a nutritional supplement, take one capsule up to 3 times daily, or as directed by your healthcare professional.

    Out of stock

    $26.00

    Out of stock

Professional Formulas Products

Professional Formulas offers a broad line of targeted macronutrients and homeopathic remedies. Professional Formulas nutritional products are manufactured in an NSF-certified, GMP-compliant facility while their homeopathic remedies are all hand-succussed in Professional Formulas own FDA-registered OTC drug facility, which is held to even higher GMP standards. Moreover, Professional Formulas source some of the highest quality ingredients in the world and they process and combine them in ways that maximize effectiveness.

Professional Formulas help practitioners to individualize treatment plans focused on specific symptoms/conditions, body systems, organs, allergens, pathogens, or toxins. Professional Formulas products are designed to work together - or with your existing protocols - to provide the body with synergistic biochemistry, vitality, and energetic stimulation.

Blog posts

View All

  • Is Adrenal Fatigue Real?

    in Wellness Is Adrenal Fatigue Real?

    Do you feel tired and fell you have less energy. You may be suffering from adrenal fatigue. Learn about some options for dealing with adrenal...

    Read more >

  • What Are Omega-3 Fatty Acids

    in Wellness What Are Omega-3 Fatty Acids

    We grew up with our parents telling us to take our fish oils daily. More and more people are now taking fish oil supplements for...

    Read more >

  • What is Thyroid Disease

    in Wellness What Is Thyroid Disease

    Thyroid symptoms can be easily managed if you understand what the thyroid is, how it works and how you can nourish it.

    Read more >

  • Natural Hormone Balance

    in Lifestyle How To Balance Your Hormones Naturally

    Hormones are used in almost every function in the body.  Managing your stress levels, eating plenty of protein, exercising and supplements can help improve your hormone...

    Read more >

  • 4